NEOGEN nitrogen plasma

CO₂ at 10,600 nm needs water as a chromophore. Nitrogen plasma ionises N₂ and dumps heat without a colour target, so pigment is not the absorption requirement. Both can denature collagen. Crust, downtime and the Fitzpatrick rules still differ.

Dermal fibroblasts lay new type I and III collagen over roughly 90 days after a thermal insult. A second and third pass land during that remodelling window. One pass is a wound. Three is how you stack the programme without asking one insult to do ninety days of work overnight.

No. It is a copper-binding tripeptide with published fibroblast gene-expression data. We keep it on a research label. The appointment is nitrogen plasma, booked with eLIVEate Me in Buckinghamshire. Nobody is pouring the vial into the handpiece.

Thermally desiccated epidermis, not a haemorrhagic scab. Keratinocytes cooked just enough to die in place and then shed as a sheet. Under it, keratinocytes migrate from hair follicles and sweat ducts. The crust is the clock starting. The result is the later dermal band.

Yes. The pulse does not need melanin to deposit energy. Darker epidermis still makes a more obvious crust and carries a higher risk of post-inflammatory pigment. Chromophore-independence is not pigment-irrelevance.

Type I's triple helix unwinds at about 60–70 °C in hydrated dermis. Instant tightening is that unwind. Delayed tightening is fibroblasts rebuilding types I and III over months, with HSP47 walking the new chains and TGF-β1 leaning the wound programme.

Heat-shock protein 47, gene SERPINH1, is the collagen-specific chaperone in the endoplasmic reticulum. After thermal injury it rises with the heat-shock programme and walks nascent procollagen so the triple helix can form. The new fibril is folded indoors. The pulse denatured the old one outside.

No. The Patriot listing is Gly-His-Lys·Cu²⁺, HPLC-characterised, labelled for laboratory use. eLIVEate's tool is a CE-marked nitrogen-plasma device. Adjacent biology. Different companies. No commission on the booking.

Meaningful neocollagenesis is a weeks-to-months clock. Histology after plasma skin regeneration still shows new type I and III at about 90 days. That is why the course exists, and why a day-three photograph is a photograph of injury.

A nitrogen-plasma resurfacing system: ultra-radiofrequency coupled into an N₂ stream, typical handpiece energy 0.8–4 J, a millisecond thermal pulse, no laser chromophore. The clinic in Buckinghamshire owns the device and the settings.